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Protein Translocation Across the Peroxisomal Membrane

2004; Springer Science+Business Media; Volume: 41; Issue: 3 Linguagem: Inglês

10.1385/cbb

1559-0283

Jorge E. Azevedo, João Costa‐Rodrigues, Carla Guimarães, Márcia E. Oliveira, Clara Sá-Miranda,

interferon and immune responses

Peroxisomal matrix proteins are synthesized on free cytosolic ribosomes and posttranslationally imported into the organelle. Translocation of these newly synthesized proteins across the peroxisomal membrane requires the concerted action of many different proteins, the majority of which were already identified. However, not much is known regarding the mechanism, of protein translocation across this membrane system. Here, we discuss recent mechanistic and structural data. These results point to a model in which proteins en route to the peroxisomal matrix are translocated across the organelle membrane by their own receptor in a process that occurs, through a large membrane protein assembly.