Exercise-Induced Premature Ventricular Beats
2004; Lippincott Williams & Wilkins; Volume: 109; Issue: 20 Linguagem: Romeno
10.1161/01.cir.0000128241.01086.9c
ISSN1524-4539
AutoresKimberly A. Selzman, Leonard S. Gettes,
Tópico(s)Cardiac Arrhythmias and Treatments
ResumoHomeCirculationVol. 109, No. 20Exercise-Induced Premature Ventricular Beats Free AccessArticle CommentaryPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessArticle CommentaryPDF/EPUBExercise-Induced Premature Ventricular BeatsShould We Do Anything Differently? Kimberly A. Selzman, MD and Leonard S. Gettes, MD Kimberly A. SelzmanKimberly A. Selzman From the Division of Cardiology, University of North Carolina at Chapel Hill. and Leonard S. GettesLeonard S. Gettes From the Division of Cardiology, University of North Carolina at Chapel Hill. Originally published25 May 2004https://doi.org/10.1161/01.CIR.0000128241.01086.9CCirculation. 2004;109:2374–2375Exercise testing has typically been used to diagnose myocardial ischemia and to risk stratify patients with known coronary disease. The interpretation of stress testing has rested largely on the development of ST-segment changes and the presence of anginal symptoms.1 Stress tests have also been used to help categorize and treat various cardiac arrhythmias.2Single ventricular premature beats (VPBs) that occur at rest or during exercise are a cause of anxiety for patients and their physicians. However, the implications of exercise-induced VPBs are unclear. The prevalence and clinical significance of VPBs during and after exercise have been investigated for many years.3,4 Most of the studies have focused on the predictive value of exercise-induced VPBs in patients referred for diagnostic exercise testing.5–9 Of these, 3 studies7–9 showed no correlation between any exercise-induced VPBs and all-cause mortality over a follow-up period of 3 to 5 years. One study showed an association between frequent VPBs and mortality, but only after 8 years,6 and another large study determined that frequent VPBs occurring after exercise might be more predictive of mortality than VPBs occurring during exercise.5See p 2417Over the last several years, 4 studies, including that by Morshedi-Meibodi et al in the present issue of Circulation,10–13 have been conducted in asymptomatic subjects with no evidence of cardiovascular disease. Busby et al10 followed 1160 men and women ranging from 21 to 96 years of age from the Baltimore Longitudinal Study of Aging for a mean of 5.6 years. Cardiac events and all-cause mortality were not increased in the 80 subjects with frequent exercise-induced VPBs when compared with an age- and gender-matched control group.Mora et al11 examined a cohort of 2994 asymptomatic women 30 to 80 years of age enrolled in the Lipid Research Prevalence study over 20 years of follow-up. There was no relationship between frequent exercise-induced VPBs and all-cause mortality, but their presence did correlate to an increased risk of cardiovascular death. This finding is in contrast to the Busby et al10 study; however, the follow-up was significantly longer.Jouven et al12 exercised 6106 asymptomatic French male civil servants ranging in age from 42 to 53 years. They reported that frequent VPBs during exercise, defined as >10% of all ventricular depolarizations during any 30-second recording, occurred in 138 (2.3%) subjects and were associated with an increased risk of cardiovascular death over a period of 23 years. They also noted that frequent VPBs occurring after exercise were associated with an increase in noncardiovascular and all-cause mortality. In the 540 (9.5%) subjects with fewer VPBs than 10% of all beats in any 30-second recording during exercise, there was no increase in either cardiovascular or noncardiovascular mortality.In the present issue of Circulation, Morshedi-Meibodi et al13 correlate exercise-induced VPBs to 15-year outcome in 2885 asymptomatic participants of the Framingham offspring study.13 They recorded VPBs in 792 (27%) of their subjects. However, the VPBs during exercise exceeded 10% of all ventricular depolarizations in only 4 (0.1%) of the participants. For that reason, they defined the VPBs as frequent when they exceeded the median of 1 VPB per 4.5 minutes of exercise (0.22 VPBs/min). They concluded that neither infrequent nor frequent VPBs during exercise were associated with a greater risk of "hard" cardiovascular end points, defined as coronary insufficiency, myocardial infarction, or sudden cardiac death. However, in their secondary analysis, frequent VPBs were associated with an increased risk of death due to coronary heart disease, stroke, heart failure, and other vascular diseases. They also reported that VPBs, both infrequent and frequent, were associated with an increased risk of all-cause mortality, with many of the deaths due to malignancy.It is difficult to compare the results of this study with those of earlier studies because the authors chose to isolate hard cardiovascular end points from "secondary" cardiovascular end points. However, there are noteworthy study design differences between this and previous studies. The cohort in this study experienced a much lower frequency of exercise-induced VPBs than in the prior studies. For this reason, the authors defined "frequent" VPBs differently than in previous studies. Unlike some of the other studies (the Jouven et al12 study, for example), subjects with VPBs at rest were excluded, and the exercise and ECG monitoring protocols and the follow-up periods differ. In addition, the age groups and percentages of women varied between the studies, and there were probably differences in racial diversity and tobacco use.Important similarities were also present. As in the present study, the study by Jouven et al12 failed to establish a relationship between less frequent VPBs and cardiovascular events, and none of the studies demonstrated an interaction between exercise-induced VPBs and ST-segment changes, indicating that the exercise-induced VPBs could not be attributed to ischemia.Morshedi-Meibodi et al13 also recorded fractional shortening, determined by echocardiogram, and concluded that the presence of exercise-induced VPBs was unaffected by ventricular systolic function.How then do these studies, taken together, impact on our understanding of the electrophysiological cause of the VPBs, their etiology, and our response to their presence?It seems reasonable to assume that the presence of VPBs indicates a region of increased excitability and that their relationship to exercise suggests catecholamine sensitivity. But the studies provide no further insight into whether the VPBs are due to reentry, to enhanced automaticity, or to afterdepolarizations. As noted above and mentioned in other editorials,14 their presence is not linked to ischemia but is related in a linear fashion to increasing age. This suggests that a change in myocardial substrate over time might have been related to the increase in cardiovascular mortality associated with frequent exercise-induced VPBs.The studies suggest that exercise-induced VPBs in asymptomatic individuals do not predict an increased risk of cardiovascular end points over the short term (5 years). Thus, there is no evidence to suggest that further evaluations other than a careful history, physical examination, and possibly an echocardiogram be routinely performed in these patients.The relationship between infrequent exercise-induced VPBs and all-cause mortality reported in the present study is difficult to interpret. Nonetheless, the possibility that exercise-induced VPBs may identify patients at risk for noncardiovascular deaths warrants additional large cohort studies to determine whether this relationship does indeed exist. In addition, the relationship between frequent exercise-related VPBs and cardiovascular end points needs further investigation. Lastly, research focused on the possible mechanisms of exercise VPBs is needed. Perhaps the relationship between exercise-induced VPBs and age, heart rate variability, heart rate turbulence, and other markers of autonomic tone would contribute to our understanding of these anxiety-producing events.The opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.FootnotesCorrespondence to Dr Leonard S. Gettes, Division of Cardiology, University of North Carolina at Chapel Hill, Bioinformatics No. 7075, 130 Mason Farm Rd, Chapel Hill, NC 27599-7075. E-mail [email protected] References 1 Rodgers GP, Ayanian JZ, Balady G, et al. American College of Cardiology/American Heart Association Clinical Competence Statement on Stress Testing. Circulation. 2000; 102: 1726–1738.CrossrefMedlineGoogle Scholar2 Woelfel A, Foster JR, Simpson RJ, et al. Reproducibility and treatment of exercise-induced ventricular tachycardia. Am J Cardiol. 1984; 53: 751–756.CrossrefMedlineGoogle Scholar3 McHenry PL, Morris SN, Kavalier M, et al. Comparative study of exercise-induced ventricular arrhythmias in normal subjects and patients with documented coronary artery disease. Am J Cardiol. 1976; 37: 609–616.CrossrefMedlineGoogle Scholar4 McHenry PL, Fisch C, Jordan JW, et al. Cardiac arrhythmias observed during maximal treadmill exercise testing in clinically normal men. Am J Cardiol. 1972; 29: 331–336.CrossrefMedlineGoogle Scholar5 Frolkis JP, Pothier CE, Blackstone EH, et al. Frequent ventricular ectopy after exercise as a predictor of death. N Engl J Med. 2003; 348: 781–790.CrossrefMedlineGoogle Scholar6 Partington S, Myers J, Cho S, et al. Prevalence and prognostic value of exercise-induced ventricular arrhythmias. Am Heart J. 2003; 145: 139–146.CrossrefMedlineGoogle Scholar7 Marieb MA, Gibson RS, et al. Clinical Relevance of Exercise-Induced Ventricular Arrhythmias in Suspected Coronary Artery Disease. Am J Cardiol. 1990; 66: 172–178.CrossrefMedlineGoogle Scholar8 Sami M, Chaitman B, Fisher L, et al. Significance of exercise-induced ventricular arrhythmia in stable coronary artery disease: a Coronary Artery Surgery Study project. Am J Cardiol. 1984; 54: 1182–1188.CrossrefMedlineGoogle Scholar9 Califf RM, McKinnis RA, McNeer F, et al. Prognostic value of ventricular arrhythmias associated with treadmill exercise testing in patients studied with cardiac catheterization for suspected ischemic heart disease. J Am Coll Cardiol. 1983; 2: 1060–1067.CrossrefMedlineGoogle Scholar10 Busby MJ, Shefrin EA, Fleg JL. Prevalence and long-term significance of exercise-induced frequent or repetitive ventricular ectopic beats in apparently healthy volunteers. J Am Coll Cardiol. 1989; 14: 1659–1665.CrossrefMedlineGoogle Scholar11 Mora S, Redberg RF, Cui Y, et al. Ability of exercise testing to predict cardiovascular and all-cause death in asymptomatic women. JAMA. 2003; 290: 1600–1607.CrossrefMedlineGoogle Scholar12 Jouven X, Zureik M, Desnos M, et al. Long-term outcome in asymptomatic men with exercise-induced premature ventricular depolarizations. N Engl J Med. 2000; 343: 826–833.CrossrefMedlineGoogle Scholar13 Morshedi-Meibodi A, Evans JC, Levy D, et al. Clinical correlates and prognostic significance of exercise-induced ventricular premature beats in the community: The Framingham Heart Study. Circulation. 2004; 109: 2417–2422.LinkGoogle Scholar14 Calkins H. Premature ventricular depolarizations during exercise. N Engl J Med. 2000; 343: 879–880.CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetailsCited By Pelliccia A, Sharma S, Gati S, Bäck M, Börjesson M, Caselli S, Collet J, Corrado D, Drezner J, Halle M, Hansen D, Heidbuchel H, Myers J, Niebauer J, Papadakis M, Piepoli M, Prescott E, Roos-Hesselink J, Graham Stuart A, Taylor R, Thompson P, Tiberi M, Vanhees L, Wilhelm M, Guazzi M, La Gerche A, Aboyans V, Adami P, Backs J, Baggish A, Basso C, Biffi A, Bucciarelli-Ducci C, Camm A, Claessen G, Delgado V, Elliott P, Galderisi M, Gale C, Gray B, Haugaa K, Iung B, Katus H, Keren A, Leclercq C, Lewis B, Mont L, Mueller C, Petersen S, Petronio A, Roffi M, Savonen K, Serratosa L, Shlyakhto E, Simpson I, Sitges M, Solberg E, Sousa-Uva M, Van Craenenbroeck E, Van De Heyning C, Wijns W, Gati S, Bäck M, Börjesson M, Caselli S, Collet J, Corrado D, Drezner J, Halle M, Hansen D, Heidbuchel H, Myers J, Niebauer J, Papadakis M, Piepoli M, Prescott E, Roos-Hesselink J, Stuart A, Taylor R, Thompson P, Tiberi M, Vanhees L, Wilhelm M, Tahmi M, Zelveian P, Berger T, Gabulova R, Sudzhaeva S, Lancellotti P, Sokolović Š, Gruev I, Velagic V, Nicolaides E, Tuka V, Rasmusen H, Khamis H, Viigimaa M, Laukkanen J, Bosser G, Hambrecht R, Kasiakogias A, Merkely B, Gunnarsson G, McAdam B, Keren A, Perrone-Filardi P, Bajraktari G, Mirrakhimov E, Rozenštoka S, Marinskis G, Banu C, Abela M, Vataman E, Belada N, Belghiti H, Jorstad H, Srbinovska-Kostovska E, Haugaa K, Główczyńska R, Dores H, Mitu F, Smolensky A, Foscoli M, Nedeljkovic I, Farsky S, Fras Z, Boraita A, Sörenssen P, Schmied C, Bsata W, Zakhama L, Uzun M, Nesukay E and Rakhit D (2020) 2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease, European Heart Journal, 10.1093/eurheartj/ehaa605, 42:1, (17-96), Online publication date: 1-Jan-2021. Pelliccia A, Sharma S, Gati S, Bäck M, Börjesson M, Caselli S, Collet J, Corrado D, Drezner J, Halle M, Hansen D, Heidbuchel H, Myers J, Niebauer J, Papadakis M, Piepoli M, Prescott E, Roos-Hesselink J, Stuart A, Taylor R, Thompson P, Tiberi M, Vanhees L and Wilhelm M (2021) Guía ESC 2020 sobre cardiología del deporte y el ejercicio en pacientes con enfermedad cardiovascular, Revista Española de Cardiología, 10.1016/j.recesp.2020.11.026, 74:6, (545.e1-545.e73), Online publication date: 1-Jun-2021. Heidbuchel H, Arbelo E, D'Ascenzi F, Borjesson M, Boveda S, Castelletti S, Miljoen H, Mont L, Niebauer J, Papadakis M, Pelliccia A, Saenen J, Sanz de la Garza M, Schwartz P, Sharma S, Zeppenfeld K, Corrado D, Heinzel F, Veltmann C, Odening K, Boldt L, Anné W, Napolitano C, Davos C, Piepoli M, Biffi A, van Buuren F, Dagres N, Boveda S, Vernooy K, Kalarus Z, Kudaiberdieva G, Mairesse G, Kutyifa V, Deneke T, Svendsen J, Traykov V, Wilde A and Heinzel F (2020) Recommendations for participation in leisure-time physical activity and competitive sports of patients with arrhythmias and potentially arrhythmogenic conditions. Part 2: ventricular arrhythmias, channelopathies, and implantable defibrillators, EP Europace, 10.1093/europace/euaa106, 23:1, (147-148), Online publication date: 27-Jan-2021. Corrado D, Drezner J, D'Ascenzi F and Zorzi A (2019) How to evaluate premature ventricular beats in the athlete: critical review and proposal of a diagnostic algorithm, British Journal of Sports Medicine, 10.1136/bjsports-2018-100529, 54:19, (1142-1148), Online publication date: 1-Oct-2020. Havránek Š (2020) (Sports and cardiac arrhythmias), Cor et Vasa, 10.33678/cor.2020.030, 62:4, (379-385), Online publication date: 16-Sep-2020. Mert K, İlgüy S, Mert G, Dural M and Iskenderov K (2018) Noninvasive predictors of cardiac arrhythmias in bodybuilders, Revista Portuguesa de Cardiologia (English Edition), 10.1016/j.repce.2018.01.007, 37:8, (693-701), Online publication date: 1-Aug-2018. Mert K, İlgüy S, Mert G, Dural M and Iskenderov K (2018) Noninvasive predictors of cardiac arrhythmias in bodybuilders, Revista Portuguesa de Cardiologia, 10.1016/j.repc.2018.01.010, 37:8, (693-701), Online publication date: 1-Aug-2018. D'Ascenzi F, Zorzi A, Alvino F, Bonifazi M, Corrado D and Mondillo S (2016) The prevalence and clinical significance of premature ventricular beats in the athlete, Scandinavian Journal of Medicine & Science in Sports, 10.1111/sms.12679, 27:2, (140-151), Online publication date: 1-Feb-2017. Kim J, Kwon M, Chang J, Harris D, Gerson M, Hwang S and Oh S (2016) Meta-Analysis of Prognostic Implications of Exercise-Induced Ventricular Premature Complexes in the General Population, The American Journal of Cardiology, 10.1016/j.amjcard.2016.06.007, 118:5, (725-732), Online publication date: 1-Sep-2016. Turan O, Ozturk M, Kocaoglu I and Turan S (2016) Blood pressure response is impaired in patients with exercise-induced ventricular ectopy, Journal of the American Society of Hypertension, 10.1016/j.jash.2016.03.179, 10:5, (447-456), Online publication date: 1-May-2016. Schmied C, Brunckhorst C, Duru F and Haegeli L (2013) Exercise Testing for Risk Stratification of Ventricular Arrhythmias in the Athlete, Cardiac Electrophysiology Clinics, 10.1016/j.ccep.2012.11.003, 5:1, (53-64), Online publication date: 1-Mar-2013. Sokolova A, Bogachev M and Bunde A (2011) Clustering of ventricular arrhythmic complexes in heart rhythm, Physical Review E, 10.1103/PhysRevE.83.021918, 83:2 Sanatani S and Gross G (2009) Right Ventricular Tachycardia Congenital Diseases in the Right Heart, 10.1007/978-1-84800-378-1_14, (111-117), . Futterman L and Lemberg L (2006) The Clinical Significance of Exercise-Induced Ventricular Arrhythmias, American Journal of Critical Care, 10.4037/ajcc2006.15.4.431, 15:4, (431-435), Online publication date: 1-Jul-2006. Narducci M, Cammarano M, Novelli V, Bisignani A, Pavone C, Perna F, Bencardino G, Pinnacchio G, Bianco M, Zeppilli P, Palmieri V and Pelargonio G (2021) Diagnostic Workflow in Competitive Athletes with Ventricular Arrhythmias and Suspected Concealed Cardiomyopathies, Medicina, 10.3390/medicina57020182, 57:2, (182) May 25, 2004Vol 109, Issue 20 Advertisement Article InformationMetrics https://doi.org/10.1161/01.CIR.0000128241.01086.9CPMID: 15159325 Originally publishedMay 25, 2004 KeywordsexercisearrhythmiaFocused PerspectivesepidemiologyPDF download Advertisement
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