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The Origin of Macromolecule Ionization by Laser Irradiation (Nobel Lecture)

2003; Wiley; Volume: 42; Issue: 33 Linguagem: Inglês

10.1002/anie.200300585

1521-3773

Koichi Tanaka,

Ion-surface interactions and analysis

Without fragmentation: The mass spectrometric analysis of biological macromolecules can be achieved without fragmentation of the parent molecule by using the technique of soft laser (matrix-assisted laser desorption/ionization (MALDI; see scheme, UFMP=ultrafine metal-powder matrix). The development of this technique was greatly influenced by the work of Koichi Tanaka for which he was awarded the Nobel Prize for Chemistry in 2002.