Recovery from Cardiac Bypass and Elective Cardiac Arrest
1974; Lippincott Williams & Wilkins; Volume: 35; Issue: 3 Linguagem: Inglês
10.1161/01.res.35.3.448
ISSN1524-4571
AutoresDavid J. Hearse, David A. Stewart, E. B. Chain,
Tópico(s)Cardiac electrophysiology and arrhythmias
ResumoHomeCirculation ResearchVol. 35, No. 3Recovery from Cardiac Bypass and Elective Cardiac Arrest Free AccessResearch ArticlePDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessResearch ArticlePDF/EPUBRecovery from Cardiac Bypass and Elective Cardiac Arrest The Metabolic Consequences of Various Cardioplegic Procedures in the Isolated Rat Heart DAVID J. HEARSE, DAVID A. STEWART and ERNST B. CHAIN DAVID J. HEARSEDAVID J. HEARSE Department of Biochemistry, Imperial College of Science and Technology, Kensington, London and The Cardiovascular Research Unit, Department of Medicine, Royal Postgraduate Medical School, DuCane Road, London, Great Britain , DAVID A. STEWARTDAVID A. STEWART Department of Biochemistry, Imperial College of Science and Technology, Kensington, London and The Cardiovascular Research Unit, Department of Medicine, Royal Postgraduate Medical School, DuCane Road, London, Great Britain and ERNST B. CHAINERNST B. CHAIN Department of Biochemistry, Imperial College of Science and Technology, Kensington, London and The Cardiovascular Research Unit, Department of Medicine, Royal Postgraduate Medical School, DuCane Road, London, Great Britain Originally published1 Sep 1974https://doi.org/10.1161/01.RES.35.3.448Circulation Research. 1974;35:448–457AbstractIsolated perfused working rat hearts were subjected to elective cardiac arrest for 20 or 30 minutes. Various methods of arrest, either singly or in combination and with or without coronary perfusion, were studied. The functional recovery of the heart following the termination of arrest was related to the concentration of adenosine triphosphate (ATP) and creatine phosphate in the myocardium at the end of the period of arrest. In turn, these concentrations depended on the method used to induce arrest. Normothermic ischemic arrest or electrical fibrillation led to a marked reduction in high-energy phosphates and a poor functional recovery. In contrast, coronary perfusion with hypothermic solutions or solutions containing high concentrations of potassium induced arrest without depleting ATP or creatine phosphate. These procedures conferred considerable protection on the myocardium and thus permitted good recovery. The energy status and the recovery associated with ischemic arrest were improved by combining the ischemia with potassium-induced arrest, intermittent coronary perfusion, or hypothermia. In the latter instance, a time- and temperature-dependent relationship was demonstrated. The results stress the importance of maintaining ATP and creatine phosphate levels during arrest; such maintenance requires the provision of a continuous supply of oxygen and nutrient, which may perhaps be best achieved by ensuring continuous and adequate coronary perfusion. Previous Back to top Next FiguresReferencesRelatedDetailsCited By Chambers D (2021) The importance of conducting relevant animal studies to advance cardioprotection for cardiac surgery , European Journal of Cardio-Thoracic Surgery, 10.1093/ejcts/ezab172, 60:4, (918-919), Online publication date: 22-Oct-2021. Ohsumi A, Chen F, Nakajima D, Sakamoto J, Yamada T, Fujinaga T, Shoji T, Sakai H, Bando T and Date H (2012) Therapeutic effect of surfactant inhalation during warm ischemia in an isolated rat lung perfusion model, Transplant International, 10.1111/j.1432-2277.2012.01532.x, 25:10, (1096-1105), Online publication date: 1-Oct-2012. 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Buckberg G, Olinger G, Mulder D and Maloney J (1975) Depressed postoperative cardiac performance, The Journal of Thoracic and Cardiovascular Surgery, 10.1016/S0022-5223(19)39646-1, 70:6, (974-988), Online publication date: 1-Dec-1975. September 1, 1974Vol 35, Issue 3 Advertisement Article InformationMetrics © 1974 American Heart Association, Inc.https://doi.org/10.1161/01.RES.35.3.448 Manuscript receivedMarch 21, 1974Manuscript acceptedMay 31, 1974Originally publishedSeptember 1, 1974 Keywordsadenosine triphosphatepotassium-induced arrestcoronary perfusionischemic arrestfibrillationhypothermic arrestcreatine phosphatePDF download Advertisement
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