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A novel 4-aminoantipyrine-Pd(II) complex catalyzes Suzuki–Miyaura cross-coupling reactions of aryl halides

2014; Beilstein Institute for the Advancement of Chemical Sciences; Volume: 10; Linguagem: Inglês

10.3762/bjoc.10.299

2195-951X

Claudia Contreras‐Celedón, Darío Mendoza‐Rayo, José Arturo Rincón‐Medina, Luis Chacón‐García,

Sulfur-Based Synthesis Techniques

A simple and efficient catalytic system based on a Pd complex of 4-aminoantipyrine, 4-AAP-Pd(II), was found to be highly active for Suzuki-Miyaura cross-coupling of aryl iodides and bromides with phenylboronic acids under mild reaction conditions. Good to excellent product yields from the cross-coupling reaction can be achieved when the reaction is carried out in ethanol, in the open air, using low loading of 4-AAP-Pd(II) as a precatalyst, and in the presence of aqueous K2CO3 as the base. A variety of functional groups are tolerated.