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Antibacterial activity of 15 - deoxygoyazensolide isolated from the stems of Minasia alpestris (Asteraceae) against oral pathogens

2011; Taylor & Francis; Volume: 25; Issue: 4 Linguagem: Inglês

10.1080/14786410903533612

1478-6427

Larissa Costa Keles, Fernanda Moreira Gianasi, Renata Carolini Souza, Belén Brito, E.H. Schaab, Maria Gorete Mendes de Souza, Tatiane Cruz de Carvalho, Carlos Henrique Gomes Martins, Rodrigo Cássio Sola Veneziani, Wilson Roberto Cunha, Antônio E. M. Crotti,

Natural product bioactivities and synthesis

This work reports the isolation of the sesquiterpene lactone 15-deoxygoyazensolide from the stems of Minasia alpestris and the evaluation of its antimicrobial activity against the following oral pathogens: Enterococcus faecalis, Streptococcus salivarius, Streptococcus sobrinus, Streptococcus mutans, Streptococcus mitis, Streptococcus sanguinis, and Lactobacillus casei. Despite the cytotoxicity and genotoxicity of other sesquiterpene lactones of the furanoheliangolide-type, our results revealed that this compound exhibits low antibacterial activity against the evaluated oral pathogens; however, an interesting selectivity against E. faecalis (minimum inhibitory concentration [MIC] = 40 µg mL−1) and S. sobrinus (MIC = 60 µg mL−1) was observed.