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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Primary resistance of human immunodeficiency virus type 1 in a reference center in Recife, Pernambuco, Brazil

2006; Instituto Oswaldo Cruz, Ministério da Saúde; Volume: 101; Issue: 8 Linguagem: Inglês

10.1590/s0074-02762006000800004

ISSN

1678-8060

Autores

Luzidalva Barbosa de Medeiros, Heloísa Ramos Lacerda, Ana Maria Salustiano Cavalcanti, Maria de Fátima Pessoa Militão de Albuquerque,

Tópico(s)

HIV Research and Treatment

Resumo

To assess the prevalence of primary resistance of human immunodeficiency virus type 1 (HIV-1) to antiretrovirals, 84 patients chronically infected with HIV without prior antiretroviral treatment from Northeast Brazil were studied. Genotyping was performed using the ViroSeqTM Genotyping System. Thimidine analog mutations occurred in 3 (3.6%) patients. Accessory mutations related to NRTI occurred in 6 (7.1%) and related to PI in 67 (79.8%). Subtypes B (72.6%), F (22.6%), B/F 3 (3.6%), and C (1.2%) were detected. A low prevalence of major mutations related to NRTI in patients chronically infected by HIV was observed.

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