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Endoplasmic Reticulum Degradation–Enhancing α‐Mannosidase–like Protein 1 Targets Misfolded HLA–B27 Dimers for Endoplasmic Reticulum–Associated Degradation

2014; Wiley; Volume: 66; Issue: 11 Linguagem: Inglês

10.1002/art.38809

2326-5205

David B. Guiliano, Helen Fussell, Izabela Lenart, Edward H. Tsao, Darren Nesbeth, Adam J. Fletcher, Elaine C. Campbell, Nasim Yousaf, Shawna Williams, Susana G. Santos, Amy Cameron, Greg J. Towers, Paul Kellam, Daniel N. Hebert, Keith G. Gould, Simon J. Powis, Antony N. Antoniou,

Galectins and Cancer Biology

HLA-B27 forms misfolded heavy chain dimers, which may predispose individuals to inflammatory arthritis by inducing endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). This study was undertaken to define the role of the UPR-induced ER-associated degradation (ERAD) pathway in the disposal of HLA-B27 dimeric conformers.