Regulation of Cell Migration by the C2 Domain of the Tumor Suppressor PTEN
2004; American Association for the Advancement of Science; Volume: 303; Issue: 5661 Linguagem: Inglês
10.1126/science.1092089
ISSN1095-9203
AutoresMyrto Raftopoulou, Sandrine Étienne-Manneville, Annette J. Self, Sarah Nicholls, Alan Hall,
Tópico(s)Polyamine Metabolism and Applications
ResumoPTEN is a tumor suppressor protein that dephosphorylates phosphatidylinositol 3,4,5 trisphosphate and antagonizes the phosphatidylinositol-3 kinase signaling pathway. We show here that PTEN can also inhibit cell migration through its C2 domain, independent of its lipid phosphatase activity. This activity depends on the protein phosphatase activity of PTEN and on dephosphorylation at a single residue, threonine(383). The ability of PTEN to control cell migration through its C2 domain is likely to be an important feature of its tumor suppressor activity.
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