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BIBTEX RIS

Kidney-Targeted Birt-Hogg-Dube Gene Inactivation in a Mouse Model: Erk1/2 and Akt-mTOR Activation, Cell Hyperproliferation, and Polycystic Kidneys

2008; Oxford University Press; Volume: 100; Issue: 2 Linguagem: Inglês

10.1093/jnci/djm288

ISSN

1460-2105

Autores

Masaya Baba, M Furihata, Seung‐Beom Hong, Lino Tessarollo, Diana C. Haines, Eileen Southon, Vishal Patel, Peter Igarashi, W. Gregory Alvord, Robert M. Leighty, Masahiro Yao, Marcelino Bernardo, Lilia Ileva, Peter L. Choyke, Michelle B. Warren, Berton Zbar, W. Marston Linehan, Laura S. Schmidt,

Tópico(s)

Genetic and Kidney Cyst Diseases

Resumo

BackgroundPatients with Birt-Hogg-Dubé (BHD) syndrome harbor germline mutations in the BHD tumor suppressor gene that are associated with an increased risk for kidney cancer. BHD encodes folliculin, a protein that may interact with the energy- and nutrient-sensing 5′-AMP-activated protein kinase-mammalian target of rapamycin (AMPK-mTOR) signaling pathways.

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