Produção Nacional
Revisado por pares
Assessment of the cytotoxic, genotoxic, and mutagenic potential of Acrocomia aculeata in rats
2015; Research Foundation of Ribeirão Preto; Volume: 14; Issue: 1 Linguagem: Inglês
10.4238/2015.january.26.13
ISSN1676-5680
AutoresGiseli Karenina Traesel, Luis Henrique Almeida Castro, P.V.B. Silva, Rozanna Marques Muzzi, Cândida Aparecida Leite Kassuya, Arielle Cristina Arena, Silvia Aparecida Oesterreich,
Tópico(s)Allelopathy and phytotoxic interactions
ResumoAcrocomia aculeata (Jacq.)Lodd.ex Mart. is a plant species commonly used as a foodstuff and also for treating diseases, since it contains high concentrations of antioxidant compounds and monounsaturated fatty acids.Considering its ethnopharmacological relevance, the aim of the present study was to assess the cytotoxic, genotoxic, and mutagenic effects of an oil extracted from the pulp of A. aculeata (OPAC) in rats.In addition, a chromatographic characterization of the fatty acids present in OPAC was performed.Male and female Wistar rats were treated orally with 125, 250, 500, 1000, or 2000 mg/ kg/body weight OPAC.The effects of OPAC ingestion were determined by performing the comet assay and micronucleus test.The comet assay data demonstrated that OPAC did not increase the frequency or rate of ©FUNPEC-RP www.funpecrp.com.br
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