Portal de Periódicos da CAPES

Total Synthesis of the Originally Proposed and Revised Structures of Palmerolide A

2007; Wiley; Volume: 46; Issue: 31 Linguagem: Inglês

10.1002/anie.200702243

1521-3773

K. C. Nicolaou, Ramakrishna Guduru, Ya‐Ping Sun, Biswadip Banerji, David Y.‐K. Chen,

Marine Sponges and Natural Products

In the palm of your hand: Total syntheses of the originally proposed and revised structures of the marine antitumor agent palmerolide A (see picture, originally proposed structure had opposite configurations at the positions indicated in red) were accomplished through a modular strategy that features a ring-closing metathesis to stereoselectively form the C8C9 bond and concurrently form the macrocycle.