The Neuropad test: a visual indicator test for human diabetic neuropathy
2008; Springer Science+Business Media; Volume: 51; Issue: 6 Linguagem: Inglês
10.1007/s00125-008-0987-y
ISSN1432-0428
AutoresCristian Quattrini, Maria Jeziorska, Mitra Tavakoli, Piyara Begum, Andrew J.M. Boulton, Rayaz A. Malik,
Tópico(s)Bee Products Chemical Analysis
ResumoThe commercially available Neuropad test was developed as a simple visual indicator test to evaluate diabetic neuropathy. It uses a colour change to define the integrity of skin sympathetic cholinergic innervation. We compared the results of Neuropad assessment in the foot with established measures of somatic and autonomic neuropathy.Fifty-seven diabetic patients underwent Neuropad assessment, quantitative sensory and autonomic function testing, and evaluation of intra-epidermal nerve fibre density in foot skin biopsies.Neuropad responses correlated with the neuropathy disability score (r(s)=0.450, p<0.001), neuropathic symptom score (r(s)=0.288, p=0.03), cold detection threshold (r(s)=0.394, p = 0.003), heat-as-pain perception threshold visual analogue score 0.5 (r(s)=0.279, p=0.043) and deep-breathing heart rate variability (r(s)= -0.525, p or=5) was 85% (negative predictive value 71%) and the specificity was 45% (positive predictive value 69%).The Neuropad test may be a simple indicator for screening patients with diabetic neuropathy.
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