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Safety and Comparative Immunogenicity of an HIV-1 DNA Vaccine in Combination with Plasmid Interleukin 12 and Impact of Intramuscular Electroporation for Delivery

2013; Oxford University Press; Volume: 208; Issue: 5 Linguagem: Inglês

10.1093/infdis/jit236

1537-6613

Spyros A. Kalams, Scott Parker, Marnie Elizaga, Barbara Metch, Srilatha Edupuganti, John Hural, Stephen De Rosa, Donald K. Carter, Kyle Rybczyk, Ian Frank, Jonathan D. Fuchs, Beryl A. Koblin, Denny H. Kim, Patrice Joseph, Michael C. Keefer, Lindsey R. Baden, John H. Eldridge, Jean Boyer, Adam Sherwat, M. Cardinali, Mary Allen, Michael Pensiero, Christopher Butler, Amir Sada Khan, Jian Yan, Niranjan Y. Sardesai, James G. Kublin, David B. Weiner,

Plant Virus Research Studies

Background. DNA vaccines have been very poorly immunogenic in humans but have been an effective priming modality in prime-boost regimens. Methods to increase the immunogenicity of DNA vaccines are needed.