Using Biomarkers to Inform Diagnosis, Guide Treatments and Track Response to Interventions in Psychotic Illnesses
2013; Future Medicine; Volume: 8; Issue: 1 Linguagem: Inglês
10.2217/bmm.13.133
ISSN1752-0371
AutoresVeronica B. Perez, Neal R. Swerdlow, David Braff, Risto Näätänen, Gregory A. Light,
Tópico(s)Music Therapy and Health
ResumoBiomarkers in MedicineVol. 8, No. 1 Theme: Biomarkers in schizophrenia - CommentaryUsing biomarkers to inform diagnosis, guide treatments and track response to interventions in psychotic illnessesVeronica B Perez, Neal R Swerdlow, David L Braff, Risto Näätänen & Gregory A LightVeronica B PerezVISN-22 Mental Illness Research, Education & Clinical Center (MIRECC), VA San Diego Healthcare System, CA 92161, USA and Department of Psychiatry, University of California San Diego, La Jolla, CA, USA, Neal R SwerdlowDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA, David L BraffDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA, Risto NäätänenCenter of Functionally Integrative Neuroscience (CFIN), University of Arhus, Arhus, Denmark and Department of Psychology, University of Tartu, Tartu, Estonia and Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland & Gregory A Light* Author for correspondenceVISN-22 Mental Illness Research, Education & Clinical Center (MIRECC), VA San Diego Healthcare System, CA 92161, USA and Department of Psychiatry, University of California San Diego, La Jolla, CA, USA. Published Online:11 Dec 2013https://doi.org/10.2217/bmm.13.133AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: mismatch negativityneuroplasticitypsychosisriskReferences1 Swerdlow NR. Are we studying and treating schizophrenia correctly? Schizophr. Res.130,1–10 (2011).Crossref, Medline, Google Scholar2 Braff D, Stone C, Callaway E, Geyer M, Glick I, Bali L. Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology15,339–343 (1978).Crossref, Medline, CAS, Google Scholar3 Swerdlow NR, Weber M, Qu Y, Light GA, Braff DL. Realistic expectations of prepulse inhibition in translational models for schizophrenia research. Psychopharmacology (Berl.)199,331–388 (2008).Crossref, Medline, CAS, Google Scholar4 Ford JM. Schizophrenia: the broken P300 and beyond. Psychophysiology36,667–682 (1999).Crossref, Medline, CAS, Google Scholar5 Roach BJ, Mathalon DH. Event-related EEG time-frequency analysis: an overview of measures and an analysis of early gamma band phase locking in schizophrenia. Schizophr. Bull.34,907–926 (2008).Crossref, Medline, Google Scholar6 Näätänen R, Gaillard AW, Mäntysalo S. Early selective-attention effect on evoked potential reinterpreted. Acta Psychol. (Amst.)42,313–329 (1978).Crossref, Medline, CAS, Google Scholar7 Butler PD, Chen Y, Ford JM et al. Perceptual measurement in schizophrenia: promising electrophysiology and neuroimaging paradigms from CNTRICS. Schizophr. Bull.38,81–91 (2012).Crossref, Medline, Google Scholar8 Light GA, Näätänen R. Mismatch negativity is a breakthrough biomarker for understanding and treating psychotic disorders. Proc. Natl Acad. Sci. USA110,15175–15176 (2013).Crossref, Medline, CAS, Google Scholar9 Nagai T, Tada M, Kirihara K, Araki T, Jinde S, Kasai K. Mismatch negativity as a 'translatable' brain marker toward early intervention for psychosis: a review. Front. Psychiatry4,115 (2013).Crossref, Medline, Google Scholar10 Belger A, Yucel GH, Donkers FC. In search of psychosis biomarkers in high-risk populations: is the mismatch negativity the one we've been waiting for? Biol. Psychiatry71,94–95 (2012).Crossref, Medline, Google Scholar11 Näätänen R, Astikainen P, Ruusuvirta T, Huotilainen M. Automatic auditory intelligence: an expression of the sensory-cognitive core of cognitive processes. Brain Res. Rev.64,123–136 (2010).Crossref, Medline, Google Scholar12 Näätänen R. The mismatch negativity: a powerful tool for cognitive neuroscience. Ear Hear.16,6–18 (1995).Crossref, Medline, CAS, Google Scholar13 Näätänen R, Teder W, Alho K, Lavikainen J. Auditory attention and selective input modulation: a topographical ERP study. Neuroreport3,493–496 (1992).Crossref, Medline, CAS, Google Scholar14 Shelley AM, Ward PB, Catts SV, Michie PT, Andrews S, McConaghy N. Mismatch negativity: an index of a preattentive processing deficit in schizophrenia. Biol. Psychiatry30,1059–1062 (1991).Crossref, Medline, CAS, Google Scholar15 Javitt DC, Steinschneider M, Schroeder CE, Vaughan HG Jr, Arezzo JC. Detection of stimulus deviance within primate primary auditory cortex: intracortical mechanisms of mismatch negativity (MMN) generation. Brain Res.667,192–200 (1994).Crossref, Medline, CAS, Google Scholar16 Catts SV, Shelley AM, Ward PB et al. Brain potential evidence for an auditory sensory memory deficit in schizophrenia. Am. J. Psychiatry152,213–219 (1995).Crossref, Medline, CAS, Google Scholar17 Javitt DC, Shelley AM, Silipo G, Lieberman JA. Deficits in auditory and visual context-dependent processing in schizophrenia: defining the pattern. Arch. Gen. Psychiatry57,1131–1137 (2000).Crossref, Medline, CAS, Google Scholar18 Michie PT. What has MMN revealed about the auditory system in schizophrenia? Int. J. Psychophysiol.42,177–194 (2001).Crossref, Medline, CAS, Google Scholar19 Umbricht D, Koller R, Schmid L et al. How specific are deficits in mismatch negativity generation to schizophrenia? Biol. Psychiatry53,1120–1131 (2003).Crossref, Medline, Google Scholar20 Umbricht D, Krljes S. Mismatch negativity in schizophrenia: a meta-analysis. Schizophr. Res.76,1–23 (2005).Crossref, Medline, Google Scholar21 Salisbury DF, Shenton ME, Griggs CB, Bonner-Jackson A, McCarley RW. Mismatch negativity in chronic schizophrenia and first-episode schizophrenia. Arch. Gen. Psychiatry59,686–694 (2002).Crossref, Medline, Google Scholar22 Oknina LB, Wild-Wall N, Oades RD et al. Frontal and temporal sources of mismatch negativity in healthy controls, patients at onset of schizophrenia in adolescence and others at 15 years after onset. Schizophr. Res.76,25–41 (2005).Crossref, Medline, CAS, Google Scholar23 Oades RD, Wild-Wall N, Juran SA, Sachsse J, Oknina LB, Röpcke B. Auditory change detection in schizophrenia: sources of activity, related neuropsychological function and symptoms in patients with a first episode in adolescence, and patients 14 years after an adolescent illness-onset. BMC Psychiatry6,7 (2006).Crossref, Medline, Google Scholar24 Salisbury DF, Kuroki N, Kasai K, Shenton ME, McCarley RW. Progressive and interrelated functional and structural evidence of post-onset brain reduction in schizophrenia. Arch. Gen. Psychiatry64,521–529 (2007).Crossref, Medline, Google Scholar25 Brockhaus-Dumke A, Tendolkar I, Pukrop R, Schultze-Lutter F, Klosterkötter J, Ruhrmann S. Impaired mismatch negativity generation in prodromal subjects and patients with schizophrenia. Schizophr. Res.73,297–310 (2005).Crossref, Medline, Google Scholar26 Umbricht DS, Bates JA, Lieberman JA, Kane JM, Javitt DC. Electrophysiological indices of automatic and controlled auditory information processing in first-episode, recent-onset and chronic schizophrenia. Biol. Psychiatry59,762–772 (2006).Crossref, Medline, Google Scholar27 Hermens DF, Ward PB, Hodge MA, Kaur M, Naismith SL, Hickie IB. Impaired MMN/P3a complex in first-episode psychosis: cognitive and psychosocial associations. Prog. Neuropsychopharmacol. Biol. Psychiatry34,822–829 (2010).Crossref, Medline, CAS, Google Scholar28 Bodatsch M, Ruhrmann S, Wagner M et al. Prediction of psychosis by mismatch negativity. Biol. Psychiatry69,959–966 (2011).Crossref, Medline, Google Scholar29 Jahshan C, Cadenhead KS, Rissling AJ, Kirihara K, Braff DL, Light GA. Automatic sensory information processing abnormalities across the illness course of schizophrenia. Psychol. Med.42,85–97 (2012).Crossref, Medline, CAS, Google Scholar30 Atkinson RJ, Michie PT, Schall U. Duration mismatch negativity and P3a in first-episode psychosis and individuals at ultra-high risk of psychosis. Biol. Psychiatry71,98–104 (2012).Crossref, Medline, Google Scholar31 Kirino E, Inoue R. The relationship of mismatch negativity to quantitative EEG and morphological findings in schizophrenia. J. Psychiatr. Res.33,445–456 (1999).Crossref, Medline, CAS, Google Scholar32 Rissling AJ, Braff DL, Swerdlow NR et al. Disentangling early sensory information processing deficits in schizophrenia. Clin. Neurophysiol.123,1942–1949 (2012).Crossref, Medline, Google Scholar33 Light GA, Swerdlow NR, Braff DL. Preattentive sensory processing as indexed by the MMN and P3a brain responses is associated with cognitive and psychosocial functioning in healthy adults. J. Cogn. Neurosci.19,1624–1632 (2007).Crossref, Medline, Google Scholar34 Kiang M, Light GA, Prugh J, Coulson S, Braff DL, Kutas M. Cognitive, neurophysiological, and functional correlates of proverb interpretation abnormalities in schizophrenia. J. Int. Neuropsychol. Soc.13,653–663 (2007).Crossref, Medline, Google Scholar35 Light GA, Braff DL. Mismatch negativity deficits are associated with poor functioning in schizophrenia patients. Arch. Gen. Psychiatry62,127–136 (2005).Crossref, Medline, Google Scholar36 Light GA, Braff DL. Stability of mismatch negativity deficits and their relationship to functional impairments in chronic schizophrenia. Am. J. Psychiatry162,1741–1743 (2005).Crossref, Medline, Google Scholar37 Light GA, Swerdlow NR, Rissling AJ et al. Characterization of neurophysiologic and neurocognitive biomarkers for use in genomic and clinical outcome studies of schizophrenia. PLoS ONE7,e39434 (2012).Crossref, Medline, CAS, Google Scholar38 Takahashi H, Rissling AJ, Pascual-Marqui R et al. Neural substrates of normal and impaired preattentive sensory discrimination in large cohorts of nonpsychiatric subjects and schizophrenia patients as indexed by MMN and P3a change detection responses. NeuroImage66C,594–603 (2012).Medline, Google Scholar39 Baldeweg T, Klugman A, Gruzelier J, Hirsch SR. Mismatch negativity potentials and cognitive impairment in schizophrenia. Schizophr. Res.69,203–217 (2004).Crossref, Medline, Google Scholar40 Näätänen R, Kujala T, Kreegipuu K et al. The mismatch negativity: an index of cognitive decline in neuropsychiatric and neurological diseases and in ageing. Brain134,3435–3453 (2011).Crossref, Medline, Google Scholar41 Kawakubo Y, Kamio S, Nose T et al. Phonetic mismatch negativity predicts social skills acquisition in schizophrenia. Psychiatry Res152,261–265 (2007).Crossref, Medline, Google Scholar42 Wynn JK, Sugar C, Horan WP, Kern R, Green MF. Mismatch negativity, social cognition, and functioning in schizophrenia patients. Biol. Psychiatry67,940–947 (2010).Crossref, Medline, Google Scholar43 Rasser PE, Schall U, Todd J et al. Gray matter deficits, mismatch negativity, and outcomes in schizophrenia. Schizophr. Bull.37,131–140 (2011).Crossref, Medline, CAS, Google Scholar44 Shaikh M, Valmaggia L, Broome MR et al. Reduced mismatch negativity predates the onset of psychosis. Schizophr. Res.134,42–48 (2012).Crossref, Medline, Google Scholar45 Perez VB, Woods SW, Roach BJ et al. Automatic auditory processing deficits in schizophrenia and clinical high-risk patients: forecasting psychosis risk with mismatch negativity. Biol. Psychiatry doi:10.1016/j.biopsych.2013.07.038 (2013) (Epub ahead of print).Google Scholar46 Murphy JR, Rawdon C, Kelleher I et al. Reduced duration mismatch negativity in adolescents with psychotic symptoms: further evidence for mismatch negativity as a possible biomarker for vulnerability to psychosis. BMC Psychiatry13,45 (2013).Crossref, Medline, Google Scholar47 Miller TJ, McGlashan TH, Rosen JL et al. Prospective diagnosis of the initial prodrome for schizophrenia based on the Structured Interview for Prodromal Syndromes: preliminary evidence of interrater reliability and predictive validity. Am. J. Psychiatry159,863–865 (2002).Crossref, Medline, Google Scholar48 Yung AR, McGorry PD. The initial prodrome in psychosis: descriptive and qualitative aspects. Aust. NZ J. Psychiatry30,587–599 (1996).Crossref, Medline, CAS, Google Scholar49 Cannon TD, Cadenhead K, Cornblatt B et al. Prediction of psychosis in youth at high clinical risk: a multisite longitudinal study in North America. Arch. Gen. Psychiatry65,28–37 (2008).Crossref, Medline, Google Scholar50 Fusar-Poli P, Bonoldi I, Yung AR et al. Predicting psychosis: meta-analysis of transition outcomes in individuals at high clinical risk. Arch. Gen. Psychiatry69,220–229 (2012).Crossref, Medline, Google Scholar51 Yang LH, Wonpat-Borja AJ, Opler MG, Corcoran CM. Potential stigma associated with inclusion of the psychosis risk syndrome in the DSM-V: an empirical question. Schizophr. Res.120,42–48 (2010).Crossref, Medline, CAS, Google Scholar52 Higuchi Y, Sumiyoshi T, Seo T, Miyanishi T, Kawasaki Y, Suzuki M. Mismatch negativity and cognitive performance for the prediction of psychosis in subjects with at-risk mental state. PLoS ONE8,e54080 (2013).Crossref, Medline, CAS, Google Scholar53 Fisher M, Holland C, Merzenich MM, Vinogradov S. Using neuroplasticity-based auditory training to improve verbal memory in schizophrenia. Am. J. Psychiatry166,805–811 (2009).Crossref, Medline, Google Scholar54 Merzenich M, Wright B, Jenkins W et al. Cortical plasticity underlying perceptual, motor, and cognitive skill development: implications for neurorehabilitation. Cold Spring Harb. Symp. Quant. Biol.61,1–8 (1996).Crossref, Medline, CAS, Google Scholar55 Rogowsky BA, Papamichalis P, Villa L, Heim S, Tallal P. Neuroplasticity-based cognitive and linguistic skills training improves reading and writing skills in college students. Front. Psychol.4,137 (2013).Crossref, Medline, Google Scholar56 Vinogradov S, Fisher M, de Villers-Sidani E. Cognitive training for impaired neural systems in neuropsychiatric illness. Neuropsychopharmacology37,43–76 (2012).Crossref, Medline, Google Scholar57 Näätänen R. Mismatch negativity (MMN) as an index of central auditory system plasticity. Int. J. Audiol.47(Suppl. 2),S16–S20 (2008).Crossref, Medline, Google Scholar58 Rissling AJ, Park SH, Young JW et al. Demand and modality of directed attention modulate 'pre-attentive' sensory processes in schizophrenia patients and nonpsychiatric controls. Schizophr. Res.146,326–335 (2013).Crossref, Medline, Google Scholar59 Lovio R, Halttunen A, Lyytinen H, Näätänen R, Kujala T. Reading skill and neural processing accuracy improvement after a 3-hour intervention in preschoolers with difficulties in reading-related skills. Brain Res.1448,42–55 (2012).Crossref, Medline, CAS, Google Scholar60 Twamley EW, Vella L, Burton CZ, Heaton RK, Jeste DV. Compensatory cognitive training for psychosis: effects in a randomized controlled trial. J. Clin. Psychiatry73,1212–1219 (2012).Crossref, Medline, Google Scholar61 Granholm E, McQuaid JR, McClure FS et al. A randomized, controlled trial of cognitive behavioral social skills training for middle-aged and older outpatients with chronic schizophrenia. Am. J. Psychiatry162,520–529 (2005).Crossref, Medline, Google Scholar62 Twamley EW, Baker DG, Norman SB, Pittman JO, Lohr JB, Resnick SG. Veterans Health Administration vocational services for Operation Iraqi Freedom/Operation Enduring Freedom Veterans with mental health conditions. J. Rehabil. Res. Dev.50,663–670 (2013).Crossref, Medline, Google Scholar63 Twamley EW, Vella L, Burton CZ, Becker DR, Bell MD, Jeste DV. The efficacy of supported employment for middle-aged and older people with schizophrenia. Schizophr. Res.135,100–104 (2012).Crossref, Medline, Google Scholar64 Braff L, Braff DL. The neuropsychiatric translational revolution: still very early and still very challenging. JAMA Psychiatry70,777–779 (2013).Crossref, Medline, Google Scholar101 Frances A. NIMH vs DSM-5: no one wins, patients lose (2013). www.huffingtonpost.com/allen-frances/nimh-vs-dsm-5-no-one-wins_b_3252323.htmlGoogle Scholar102 Hyman SE. Psychiatric drug development: diagnosing a crisis (2013). www.dana.org/news/cerebrum/detail.aspx?id=41290Google ScholarFiguresReferencesRelatedDetailsCited ByDeep psychophysiological phenotyping of adolescents and adults with 22q11.2 deletion syndrome: a multilevel approach to defining core disease processes13 June 2023 | BMC Psychiatry, Vol. 23, No. 1Adjuvant electroconvulsive therapy with antipsychotics is associated with improvement in auditory mismatch negativity in schizophreniaPsychiatry Research, Vol. 311A hippocampus dependent neural circuit loop underlying the generation of auditory mismatch negativityNeuropharmacology, Vol. 206Test-retest reliability of mismatch negativity and gamma-band auditory steady-state response in patients with schizophreniaSchizophrenia Research, Vol. 240Searching for Imaging Biomarkers of Psychotic DysconnectivityBiological Psychiatry: Cognitive Neuroscience and Neuroimaging, Vol. 6, No. 12Ensemble classification of autism spectrum disorder using structural magnetic resonance imaging features6 November 2021 | JCPP Advances, Vol. 1, No. 3Effects of methylphenidate on mismatch negativity and P3a amplitude of initially psychostimulant-naïve, adult ADHD patients5 July 2021 | Psychological Medicine, Vol. 49Resting-state network topology characterizing callous-unemotional traits in adolescenceNeuroImage: Clinical, Vol. 32Oscillatory biomarkers of early auditory information processing predict cognitive gains following targeted cognitive training in schizophrenia patientsSchizophrenia Research, Vol. 215Mismatch negativity reveals plasticity in cortical dynamics after 1-hour of auditory training exercisesInternational Journal of Psychophysiology, Vol. 145Peripheral levels of superoxide dismutase and glutathione peroxidase in youths in ultra-high risk for psychosis: a pilot study17 December 2017 | CNS Spectrums, Vol. 24, No. 03Neurophysiologic measures of target engagement predict response to auditory-based cognitive training in treatment refractory schizophrenia30 October 2018 | Neuropsychopharmacology, Vol. 44, No. 3Mismatch Negativity is a Sensitive and Predictive Biomarker of Perceptual Learning During Auditory Cognitive Training in Schizophrenia31 January 2017 | Neuropsychopharmacology, Vol. 42, No. 11Mismatch negativity and P3a amplitude in young adolescents with first-episode psychosis: a comparison with ADHD25 October 2016 | Psychological Medicine, Vol. 47, No. 2Assessing the internal consistency of the event‐related potential: An example analysis20 December 2016 | Psychophysiology, Vol. 54, No. 1Peripheral immuno-inflammatory abnormalities in ultra-high risk of developing psychosisSchizophrenia Research, Vol. 176, No. 2-3Mismatch negativity (MMN) as biomarker predicting psychosis in clinically at-risk individualsBiological Psychology, Vol. 116Measuring the capacity for auditory system plasticity: An examination of performance gains during initial exposure to auditory-targeted cognitive training in schizophreniaSchizophrenia Research, Vol. 172, No. 1-3Metabolomic Profiling of Post-Mortem Brain Reveals Changes in Amino Acid and Glucose Metabolism in Mental Illness Compared with ControlsComputational and Structural Biotechnology Journal, Vol. 14Déficit en el procesamiento auditivo subcortical en pacientes esquizofrénicos. Revisión sobre posibles biomarcadores neurofisiológicosPsiquiatría Biológica, Vol. 22, No. 3Future clinical uses of neurophysiological biomarkers to predict and monitor treatment response for schizophrenia9 March 2015 | Annals of the New York Academy of Sciences, Vol. 1344, No. 1Validation of mismatch negativity and P3a for use in multi-site studies of schizophrenia: Characterization of demographic, clinical, cognitive, and functional correlates in COGS-2Schizophrenia Research, Vol. 163, No. 1-3Mismatch negativity (MMN) deficiency: A break-through biomarker in predicting psychosis onsetInternational Journal of Psychophysiology, Vol. 95, No. 3Animal Models of Deficient Sensorimotor Gating in Schizophrenia: Are They Still Relevant?Electroencephalographic Biomarkers of Psychosis: Present and FutureBiological Psychiatry, Vol. 77, No. 2Comparison of the Heritability of Schizophrenia and Endophenotypes in the COGS-1 Family Study5 June 2014 | Schizophrenia Bulletin, Vol. 40, No. 6The Auditory Brain-Stem Response to Complex Sounds: A Potential Biomarker for Guiding Treatment of Psychosis13 October 2014 | Frontiers in Psychiatry, Vol. 5Mismatch Negativity (MMN) as an Index of Cognitive Dysfunction17 May 2014 | Brain Topography, Vol. 27, No. 4Biomarkers in schizophreniaGabriel Vargas11 December 2013 | Biomarkers in Medicine, Vol. 8, No. 1Cortical substrates and functional correlates of auditory deviance processing deficits in schizophreniaNeuroImage: Clinical, Vol. 6Neurophysiological Biomarkers Informing the Clinical Neuroscience of Schizophrenia: Mismatch Negativity and Prepulse Inhibition of Startle22 May 2014 Vol. 8, No. 1 STAY CONNECTED Metrics Downloaded 112 times History Published online 11 December 2013 Published in print January 2014 Information© Future Medicine LtdKeywordsmismatch negativityneuroplasticitypsychosisriskFinancial & competing interests disclosureThis work was supported by the National Alliance for Research on Schizophrenia and Depression/Brain and Behavior Research Foundation, and grants from the UCSD Clinical & Translational Research Institute, Department of Veteran's Affairs (VISN 22 Mental Illness Research, Education and Clinical Center), and the National Institute of Mental Health (MH079777, MH042228, MH065571, UL RR031980 and UL 1TR000100). NR Swerdlow is a consultant for Neurocrine, Inc. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download
Referência(s)