Portal de Periódicos da CAPES

INITIAL CLINICAL TRIAL OF THE NITROGEN MUSTARD ANALOGUES OF CHLOROQUINE AND QUINACRINE: A PRELIMINARY REPORT

1958; Wiley; Volume: 68; Issue: 3 Linguagem: Inglês

10.1111/j.1749-6632.1958.tb42676.x

1749-6632

Ralph Jones, Ulfar Jonsson, Melissa H. Brown, Howard E. Lessner, Charles C. Price, Aarohi Sen,

Carcinogens and Genotoxicity Assessment

Annals of the New York Academy of SciencesVolume 68, Issue 3 p. 1133-1150 INITIAL CLINICAL TRIAL OF THE NITROGEN MUSTARD ANALOGUES OF CHLOROQUINE AND QUINACRINE: A PRELIMINARY REPORT Ralph Jones Jr., Ralph Jones Jr. Department of Medicine, University of Miami, Coral Gables, Fla. Department of Chemistry, University of Pennsylvania, Philadelphia, Pa.Search for more papers by this authorUlfar Jonsson, Ulfar Jonsson Department of Medicine, University of Miami, Coral Gables, Fla. Department of Chemistry, University of Pennsylvania, Philadelphia, Pa.Search for more papers by this authorMelissa Browning, Melissa Browning Department of Medicine, University of Miami, Coral Gables, Fla. Department of Chemistry, University of Pennsylvania, Philadelphia, Pa.Search for more papers by this authorHoward Lessner, Howard Lessner Department of Medicine, University of Miami, Coral Gables, Fla. Department of Chemistry, University of Pennsylvania, Philadelphia, Pa. Clinical Fellow, American Cancer Society.Search for more papers by this authorC. C. Price, C. C. Price Department of Medicine, University of Miami, Coral Gables, Fla. Department of Chemistry, University of Pennsylvania, Philadelphia, Pa.Search for more papers by this authorA. K. Sen, A. K. Sen Department of Medicine, University of Miami, Coral Gables, Fla. Department of Chemistry, University of Pennsylvania, Philadelphia, Pa.Search for more papers by this author Ralph Jones Jr., Ralph Jones Jr. Department of Medicine, University of Miami, Coral Gables, Fla. Department of Chemistry, University of Pennsylvania, Philadelphia, Pa.Search for more papers by this authorUlfar Jonsson, Ulfar Jonsson Department of Medicine, University of Miami, Coral Gables, Fla. Department of Chemistry, University of Pennsylvania, Philadelphia, Pa.Search for more papers by this authorMelissa Browning, Melissa Browning Department of Medicine, University of Miami, Coral Gables, Fla. Department of Chemistry, University of Pennsylvania, Philadelphia, Pa.Search for more papers by this authorHoward Lessner, Howard Lessner Department of Medicine, University of Miami, Coral Gables, Fla. Department of Chemistry, University of Pennsylvania, Philadelphia, Pa. Clinical Fellow, American Cancer Society.Search for more papers by this authorC. C. Price, C. C. Price Department of Medicine, University of Miami, Coral Gables, Fla. Department of Chemistry, University of Pennsylvania, Philadelphia, Pa.Search for more papers by this authorA. K. Sen, A. K. Sen Department of Medicine, University of Miami, Coral Gables, Fla. Department of Chemistry, University of Pennsylvania, Philadelphia, Pa.Search for more papers by this author First published: April 1958 https://doi.org/10.1111/j.1749-6632.1958.tb42676.xCitations: 12 The investigation on which this paper is based was supported in part by Research Grants C-2189 (University of Pennsylvania) and C-2993 and C-2822 (University of Miami) from the National Cancer Institute, Public Health Service, Bethesda, Md. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Schmidt, L. H. 1946. In A Survey of Antimalarial Drugs, 1941–1945. F. Y. Wiselogle, Ed. J. W. Edwards, Inc. Ann Arbor , Mich . 2 Berliner, R. W., D. P. Earle, Jr., J. V. Taggart, C. G. Zubrod, W. I. Welch, N. I. Conan, E. Bauman, S. T. Scudder & J. A. Shannon. 1948. Studies of the chemotherapy of the human malarias. VI. The physiological disposition, antimalarial activity, and toxicity of several derivatives of 4-aminoquinoline. J. Clin. Invest. 27(Suppl.): 98–107. 3 F. Y. Wiselogle, Ed. 1946. A Survey of Antimalarial Drugs, 1941–1945. J. W. Edwards, Inc. Ann Arbor , Mich . 4 Parker, F. S. & J. L. Irvin. 1952. The interaction of chloroquine with nucleic acids and nucleoproteins. J. Biol. Chem. 199: 897–909. 5 Irvin, J. L., E. M. Irvin & F. S. Parker. 1949. Interaction of antimalarials with nucleic acids; acridines and quinolines. Science. 110: 426–428. 6 Jones, R. Jr., C. C. Price & A. K. Sen. 1957. The nitrogen mustards related to chloroquine, quinacrine, and pamaquine. J. Org. Chem. 22: 783. 7 McNair-Scott, D. B., & J. S. Gots. Personal communication. 8 Creech, H. J. 1958. Discussion: Part II. Ann. N. Y. Acad. Sci. 68(3): 868. 9 McKenzie, D., W. F. Dunning & R. Jones, Jr. Unpublished observations. 10 Schmidt, L. H. Unpublished observations. 11 Karnofsky, D. A. 1950. Nitrogen mustards in the treatment of neoplastic disease. Advances in Internal Med. 4: 1–46. Citing Literature Volume68, Issue3Comparative Clinical and Biological Effects of Alkylating AgentsApril 1958Pages 1133-1150 ReferencesRelatedInformation