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Metal–Organic Frameworks as Efficient Materials for Drug Delivery

2006; Wiley; Volume: 45; Issue: 36 Linguagem: Inglês

10.1002/anie.200601878

1521-3773

Patricia Horcajada, Christian Serre, Maria Vallet‐Regí, Muriel Sebban, Françis Taulelle, Gérard Férey,

Crystallography and molecular interactions

Fill 'em up: The metal carboxylates MIL-100 and MIL-101 act as porous matrices (see picture; MIL=Materials of Institut Lavoisier) for drug-delivery systems using Ibuprofen as a model substrate. Very large amounts of the drug could be incorporated, up to an unprecedented capacity of 1.4 g of drug per gram of porous solid for MIL-101, and the total release of Ibuprofen was achieved under physiological conditions in 3 (MIL-100) and 6 days (MIL-101). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z601878_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.