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Ultra‐rapid Synthesis of 15 O‐Labeled 2‐Deoxy‐ D ‐glucose for Positron Emission Tomography (PET)

2005; Wiley; Volume: 44; Issue: 18 Linguagem: Inglês

10.1002/anie.200500044

1521-3773

Hideki Yorimitsu, Yoshihiro Murakami, Hiroyuki Takamatsu, Shintaro Nishimura, Eiichi Nakamura,

Advanced MRI Techniques and Applications

Make it quick! The oxygen isotope 15O has a half-life of only 2 min, and was incorporated into a sugar through an ultra-rapid radical hydroxylation of 2,6-dideoxy-6-iodo-D-glucose with labeled molecular oxygen to provide 6-[15O]-2-deoxy-D-glucose (see scheme). The product accumulates in metabolically active organs of rats similarly to a 18F-based tracer in common use, and represents a promising alternative for medical imaging. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z500044_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.