Myocardial stiffness is an important determinant of the plasma brain natriuretic peptide concentration in patients with both diastolic and systolic heart failure
2006; Oxford University Press; Volume: 27; Issue: 7 Linguagem: Inglês
10.1093/eurheartj/ehi772
ISSN1522-9645
AutoresSatoshi Watanabe, Junya Shite, Hideyuki Takaoka, Toshiro Shinke, Yusuke Imuro, Toru Ozawa, Hiromasa Otake, Daisuke Matsumoto, Daisuke Ogasawara, Oscar Luis Paredes, Mitsuhiro Yokoyama,
Tópico(s)Advanced Battery Technologies Research
ResumoAims Plasma brain natriuretic peptide (BNP) concentration increases in proportion to heart failure (HF) severity. Although plasma BNP decreases to a certain level by optimal treatment, there is significant heterogeneity in the baseline value among individuals. The underlying mechanism of the steady-state plasma BNP levels remains still controversial. We investigated the hypothesis that myocardial stiffness (Km) is a major determinant of the plasma BNP level.
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