Implantation and early pregnancy: Endometrial Th2 cytokine expression throughout the menstrual cycle and early pregnancy
1996; Oxford University Press; Volume: 11; Issue: 8 Linguagem: Inglês
10.1093/oxfordjournals.humrep.a019480
ISSN1460-2350
AutoresJoel Krasnow, David J. Tollerud, Gregory J. Naus, Julie A. DeLoia,
Tópico(s)Estrogen and related hormone effects
ResumoEmbryonic implantation and maintenance of pregnancy is influenced by the maternal immunological response. Type 2 T-helper (Th2) cells secrete interleukins 4, 5, 6 and 10 and are associated with suppression of cell-mediated immunity. Temporal changes in the expression of these cytokines were detectable by immunohistochemistry throughout the menstrual cycle. In pregnancy, 10-fold or greater increases in interleukin 6 and 10 secretion were detectable by enzyme-linked immunoassay compared with the non-pregnant state. The pattern of expression of Th2 cytokines suggests that progesterone may Influence endo metrial cytokine secretion. During pregnancy, Th2 expression paralleled that of viinentin, a stromal cell marker, suggesting that these cells may be a principal source of these cytokines in the gravid uterus. Increased secretion of Th2 cytokines may be a mechanism of suppressing cell- mediated immunity in the endometriuin, which may in turn enhance embryonic implantation and maintenance of pregnancy.
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