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Association of ABO histo‐blood group B allele with myocardial infarction

2003; Wiley; Volume: 30; Issue: 3 Linguagem: Inglês

10.1046/j.1365-2370.2003.00390.x

1365-2370

Urs E. Nydegger, Walter A. Wuillemin, Friedgard Julmy, Barbara J Meyer, Thierry Carrel,

Blood disorders and treatments

Summary To investigate a possible association of ABO blood group alleles with myocardial infarction, a case–control study comprising 177 patients (median age 57.0 years; range 32–72 years) and 89 controls was performed. The distributions of the ABO blood‐genotype O 1 , O 2 , A 1 , A 2 and B alleles were assessed by analysis of genomic DNA, using the sequence‐specific primer–polymerase chain reaction (PCR‐SSP) technique to investigate exons VI and VII on chromosome 9. The prevalence of the B allele was 2.5 times higher amongst patients with a history of myocardial infarction than amongst controls (16.3 vs. 6.7%; P = 0.034, Fisher's exact test). There was an association between patients carrying the B allele and myocardial infarction, with an odds ratio (OR) of 2.7 (95% confidence interval 1.1–6.8). The B allele remained an independent risk factor for myocardial infarction ( P = 0.038) when classical risk factors were adjusted for by unconditional logistic regression. In conclusion, the ABO blood group B allele was found to be an independent risk factor for myocardial infarction.