Chiral Lewis Acid Catalysis in Aqueous Media. Catalytic Asymmetric Aldol Reactions of Silyl Enol Ethers with Aldehydes in a Protic Solvent Including Water
1999; Oxford University Press; Volume: 28; Issue: 1 Linguagem: Inglês
10.1246/cl.1999.71
ISSN1348-0715
AutoresShū Kobayashi, Satoshi Nagayama, Tsuyoshi Busujima,
Tópico(s)Inorganic and Organometallic Chemistry
ResumoAbstract Chiral copper(II)-catalyzed asymmetric aldol reactions of silyl enol ethers with aldehydes have been successfully carried out in a water-ethanol solution. The use of the protic solvent including water is essential in these reactions, and this report has proposed and demonstrated a new concept for solvents in catalytic asymmetric aldol reactions.
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