Effects of calcium chelators on intracellular calcium and excitotoxicity
1993; Elsevier BV; Volume: 150; Issue: 2 Linguagem: Inglês
10.1016/0304-3940(93)90518-p
ISSN1872-7972
Autores Tópico(s)Receptor Mechanisms and Signaling
ResumoIn an attempt to probe the relationship between excitotoxicity and increases in intracellular calcium ([Ca2+]i), BAPTA-AM and its analogs were applied to cultured hippocampal neurons. Chelation of [Ca2+]i depressed and prolonged transient responses to glutamate and did not effect elevation of [Ca2+]i by prolonged exposure. This explains the inability of the chelators to prevent glutamate-induced toxicity.
Referência(s)