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Simultaneous determination of amitriptyline, imipramine and perphenazine in pharmaceutical preparations and blood serum by multi-wavelength spectrophotometry

1991; Elsevier BV; Volume: 252; Issue: 1-2 Linguagem: Inglês

10.1016/0003-2670(91)87203-j

1873-4324

José García-Fraga, Ana I. Jiménez‐Abizanda, Francisco Jiménez Moreno, Juan José Arias León,

Antibiotics Pharmacokinetics and Efficacy

Several methods were developed for the simultaneous determination of the binary mixtures amitriptyline—imipramine (1.00–10 μg ml−1), amitriptyline—perphenazine (1.00–30.00 and 1.00–8.00 μg ml−1) and imipramine—perphenazine (1.00–30.00 and 1.00–8.00 μg ml−1) and the ternary mixture amitriptyline—perphenazine—imipramine using a diode-array spectrophotometer and a multi-component analysis program. The methods were applied to the determination of the components of synthetic perphenazine—imipramine mixtures, real amitriptyline—imipramine and amitriptyline—imipramine—perphenazine mixtures in blood serum and real amitriptyline—perphenazine mixtures in pharmaceutical preparations.