Salvage therapy with lenalidomide and dexamethasone in relapsed primary plasma cell leukemia
2008; Elsevier BV; Volume: 32; Issue: 10 Linguagem: Inglês
10.1016/j.leukres.2008.03.013
ISSN1873-5835
AutoresPellegrino Musto, Giuseppe Pietrantuono, Roberto Guariglia, Oreste Villani, Maria Carmen Martorelli, Fiorella D’Auria, Antonia Zonno, Rosa Lerose,
Tópico(s)Protein Degradation and Inhibitors
ResumoPrimary plasma cell leukemia (PPCL) is a rare and aggressive plasma cell disorder. The use of novel agents, together with autologous stem cell transplantation, has improved survival outcome in PPCL. However, the prognosis is still very poor, and the optimal treatment remains an unmet clinical need.We studied the efficacy and prognostic impact of novel agents in 46 patients with PPCL patients at the Blood Diseases Hospital in China. We examined the impact of clinical and laboratory features, as well as therapies (bortezomib- and/or immunomodulatory drug–based therapies, chemotherapy) on survival and extent of clinical response, including progression-free survival and overall survival (OS). Progression-free survival and OS were assessed by the Kaplan-Meier method, and survival distributions were compared by log-rank test.In our cohort of 46 PPCL patients, the median age at the time of diagnosis was 54 years. Overall response rate was 54% (25/46). The median (95% confidence interval) progression-free survival time was 6 (0-12.5) months, and OS time was 14 (4.6-23.4) months. The OS time was significantly longer in patients treated with bortezomib-based versus non–bortezomib-based therapies (median [95% confidence interval], 19 [9-28.9] vs. 5 [4-24] months; P = .019).This large single-center study of PPCL supports the use of bortezomib-based therapies as frontline treatment in PPCL patients.
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