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Sustained remission from depressive-like behavior depends on hippocampal neurogenesis

2013; Springer Nature; Volume: 3; Issue: 1 Linguagem: Inglês

10.1038/tp.2012.141

2158-3188

António Mateus‐Pinheiro, Luísa Pinto, João M. Bessa, Mónica Morais, Nuno Dinis Alves, Susana Monteiro, Patrícia Patrício, Osborne F. X. Almeida, Nuno Sousa,

Neuroscience and Neuropharmacology Research

Impairment of hippocampal neurogenesis has been associated with the expression of depressive-like symptoms and some studies have suggested neurogenesis as a critical factor in the normalization of behavior by antidepressant (AD) drugs. This study provides robust evidence that ongoing neurogenesis is essential for the maintenance of behavioral homeostasis and that its pharmacological arrest precipitates symptoms commonly found in depressed patients. Further, the incorporation of newly born neurons and astrocytes into the preexisting hippocampal neurocircuitry is shown to be necessary for the spontaneous recovery from the adverse effects of stress and for long-term benefits of AD treatments.