PLATINUM: a web tool for analysis of hydrophobic/hydrophilic organization of biomolecular complexes
2009; Oxford University Press; Volume: 25; Issue: 9 Linguagem: Inglês
10.1093/bioinformatics/btp111
ISSN1367-4811
AutoresTimothy V. Pyrkov, Anton O. Chugunov, Nikolay A. Krylov, Dmitry E. Nolde, Roman G. Efremov,
Tópico(s)Bioinformatics and Genomic Networks
ResumoAbstract Summary: The PLATINUM (Protein–Ligand ATtractions Investigation NUMerically) web service is designed for analysis and visualization of hydrophobic/hydrophilic properties of biomolecules supplied as 3D-structures. Furthermore, PLATINUM provides a number of tools for quantitative characterization of the hydrophobic/hydrophilic match in biomolecular complexes e.g. in docking poses. These complement standard scoring functions. The calculations are based on the concept of empirical Molecular Hydrophobicity Potential (MHP). Availability: The PLATINUM web tool as well as detailed documentation and tutorial are available free of charge for academic users at http://model.nmr.ru/platinum/. PLATINUM requires Java 5 or higher and Adobe Flash Player 9. Contact: pyrkov@nmr.ru Supplementary information: Supplementary data are available at Bioinformatics online.
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