OXA-24 Carbapenemase Gene Flanked by XerC/XerD-Like Recombination Sites in Different Plasmids from Different Acinetobacter Species Isolated during a Nosocomial Outbreak
2010; American Society for Microbiology; Volume: 54; Issue: 6 Linguagem: Inglês
10.1128/aac.01674-09
ISSN1098-6596
AutoresMaría Merino, Joshi Acosta, Margarita Poza, Francisca Sanz, Alejandro Beceiro, Fernando Cháves, Germán Bou,
Tópico(s)Infections and bacterial resistance
ResumoA clinical strain of Acinetobacter calcoaceticus resistant to carbapenems was isolated from a blood culture sample from an inpatient in a hospital in Madrid (Spain) during a large outbreak of infection (affecting more than 300 inpatients), caused by a multidrug-resistant Acinetobacter baumannii clone. The carbapenem resistance in both the A. calcoaceticus and A. baumannii clones was due to a bla(OXA-24) gene harbored in different plasmids. The plasmids were fully sequenced, revealing the presence of site-specific recombination binding sites putatively involved in mobilization of the bla(OXA-24) gene. Comparison of plasmids contained in the two strains revealed possible horizontal transmission of resistance genes between the Acinetobacter species.
Referência(s)