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Real‐Time Detection of Protein–Water Dynamics upon Protein Folding by Terahertz Absorption Spectroscopy

2008; Wiley; Volume: 47; Issue: 34 Linguagem: Inglês

10.1002/anie.200802281

1521-3773

Seung Joong Kim, Benjamin Born, Martina Havenith, Martin Gruebele,

Plant Pathogens and Resistance

Take a look around: Kinetic terahertz absorption (KITA) spectroscopy has been used to monitor the attenuation and phase shift of a terahertz electric field transmitted through a protein during refolding. Comparison with data from fluorescence, circular dichroism, and small angle X-ray scattering shows that KITA monitors rearrangements of the hydration water–protein interactions during early collapse and secondary structure formation. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.