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Borderline personality features possibly related to cingulate and orbitofrontal cortices dysfunction due to schizencephaly

2008; Elsevier BV; Volume: 110; Issue: 4 Linguagem: Inglês

10.1016/j.clineuro.2007.12.009

1872-6968

Felipe Filardi da Rocha, Leandro Fernandes Malloy‐Diniz, Karla Cristhina Alves de Sousa, Hugo Alejandro Cano Prais, Humberto Corrêa, Antônio Lúcio Teixeira,

Mental Health and Psychiatry

Prefrontal cortex dysfunction has been associated with a series of behavioral symptoms, such as impulsivity and affective instability, which are the defining features of several personality disorders, notably, borderline personality disorder. We report on a 27-year-old patient with schizencephaly in the right frontal lobe (cingulate cortex lesion and secondary orbitofrontal cortex dysfunction) presenting with prominent borderline features and compromise of executive functions, decision-making and attention. We hypothesize that the personality disorder of our patient could be related to cingulate cortex lesion and secondary orbitofrontal cortex dysfunction associated with schizencephaly.