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BIBTEX RIS

Transmission Clustering Drives the Onward Spread of the HIV Epidemic Among Men Who Have Sex With Men in Quebec

2011; Oxford University Press; Volume: 204; Issue: 7 Linguagem: Inglês

10.1093/infdis/jir468

ISSN

1537-6613

Autores

Bluma Brenner, Michel Roger, David A. Stephens, Daniela Moïsi, Isabelle Hardy, Jonathan Weinberg, Reuven Turgel, Hugues Charest, James S. Koopman, Mark A. Wainberg,

Tópico(s)

HIV Research and Treatment

Resumo

Phylodynamic analysis and epidemiologic data identified 3 patterns of spread of primary human immunodeficiency virus type 1 infection (PHI) among men who have sex with men (2001-2009): 420 unique PHIs, 102 small clusters (2-4 PHIs per cluster, n = 280), and 46 large clusters (5-31 PHIs per cluster, n = 450). Large clusters disproportionately increased from 25.2% of PHIs in 2005 to 39.1% in 2009 (χ(2) = 33.9, P < .001). Scalar expansion of large clusters over 11 months (interquartile range, 3.5-25.5 months) correlated with cluster membership size (r(2) = 0.174, F = 4.424, P = .047). PHI cohort data revealed variations in social networks and risk behaviors among the 3 groups, suggesting the need for tailored prevention measures.

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