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The Hippo pathway: regulators and regulations

2013; Cold Spring Harbor Laboratory Press; Volume: 27; Issue: 4 Linguagem: Inglês

10.1101/gad.210773.112

1549-5477

Fa‐Xing Yu, Kun‐Liang Guan,

Hippo pathway signaling and YAP/TAZ

Control of cell number is crucial in animal development and tissue homeostasis, and its dysregulation may result in tumor formation or organ degeneration. The Hippo pathway in both Drosophila and mammals regulates cell number by modulating cell proliferation, cell death, and cell differentiation. Recently, numerous upstream components involved in the Hippo pathway have been identified, such as cell polarity, mechanotransduction, and G-protein-coupled receptor (GPCR) signaling. Actin cytoskeleton or cellular tension appears to be the master mediator that integrates and transmits upstream signals to the core Hippo signaling cascade. Here, we review regulatory mechanisms of the Hippo pathway and discuss potential implications involved in different physiological and pathological conditions.