Halogenation Strategies In Natural Product Biosynthesis
2008; Elsevier BV; Volume: 15; Issue: 2 Linguagem: Inglês
10.1016/j.chembiol.2008.01.006
ISSN1879-1301
AutoresChristopher S. Neumann, Danica Galonić Fujimori, Christopher T. Walsh,
Tópico(s)Marine Sponges and Natural Products
ResumoHalogenation is a frequent modification of secondary metabolites and can play a significant role in establishing the bioactivity of a compound. Enzymatic halogenation through oxidative mechanisms is the most common route to these metabolites, though direct halogenation via halide anion incorporation is also known to proceed through both enzymatic and nonenzymatic pathways. In this article, we review the current state of knowledge regarding the mechanisms of these transformations, highlight applications of this knowledge, and propose future opportunities and challenges for the field.
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