Enhanced Signaling Downstream of Ribonucleic Acid-Activated Protein Kinase-Like Endoplasmic Reticulum Kinase Potentiates Lipotoxic Endoplasmic Reticulum Stress in Human Islets
2010; Oxford University Press; Volume: 95; Issue: 3 Linguagem: Inglês
10.1210/jc.2009-2322
ISSN1945-7197
AutoresLaurence Ladrière, Mariana Igoillo‐Esteve, Daniel A. Cunha, Jean‐Pierre Brion, Marco Bugliani, Piero Marchetti, Décio L. Eizirik, Miriam Cnop,
Tópico(s)Diabetes and associated disorders
ResumoBackground: Free fatty acids cause pancreatic β-cell apoptosis and may contribute to β-cell loss in type 2 diabetes via the induction of endoplasmic reticulum (ER) stress. Eukaryotic translation initiation factor 2α (eIF2α) phosphorylation is an adaptive response to ER stress, and reductions in eIF2α phosphorylation trigger β-cell failure. Salubrinal inhibits eIF2α dephosphorylation and has been proposed as a novel therapy for diabetes.
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