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Prevalence of human papillomavirus infection in the urinary tract of men with urethritis

2010; Wiley; Volume: 17; Issue: 6 Linguagem: Inglês

10.1111/j.1442-2042.2010.02521.x

1442-2042

Kazuyoshi Shigehara, Toshiyuki Sasagawa, Syohei Kawaguchi, Yoshitomo Kobori, Takao Nakashima, Masayoshi Shimamura, Tadashi Taya, Keiichi Furubayashi, Mikio Namiki,

Urological Disorders and Treatments

To investigate the prevalence of human papillomavirus (HPV) in the genital and urinary tract of men with urethritis.Cell samples were collected from the penis, urethra and urine of 142 men with urethritis. A HPV test was performed on the samples using the modified GP5+/6+ polymerase chain reaction method, and the HPV genotype was determined using a HPV GenoArray test.Out of 142 urethritis patients, HPV was detected in 48% (68 cases), and high-risk HPV was found in 32% (46 cases) of patients, on their penis or in the urinary tract (urethra or urine). HPV was detected in 31% in the penis, 20% in the urethra and 24% in the urine, while high-risk HPV was identified in 23% in the penis, 12% in the urethra and 11% in the urine. Among the HPV-positive men, 66% had HPV infection in the urinary tract where the most common HPV types were HPV6, HPV16, HPV18 and HPV58. Single HPV-type infection was more frequently found in the urinary tract (89%) than in the penis (65%) (P < 0.05).Similar to the penis, the urinary tract represents a common HPV infection site in men with urethritis.