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No association between the angiotensin-converting enzyme ID polymorphism and elite endurance athlete status

2000; American Physiological Society; Volume: 88; Issue: 5 Linguagem: Inglês

10.1152/jappl.2000.88.5.1571

8750-7587

Tuomo Rankinen, Bernd Wolfarth, Jean‐Aimé Simoneau, Dirk Maier-Lenz, Rainer Rauramaa, Miguel A. Rivera, Marcel R. Boulay, Marie‐Christine Chagnon, Louis Pérusse, Joseph Keul, Claude Bouchard,

Behavioral Health and Interventions

Several studies have reported that the insertion (I) allele of the angiotensin-converting enzyme ( ACE) I/deletion (D) polymorphism is associated with enhanced responsiveness to endurance training and is more common in endurance athletes than in sedentary controls. We tested the latter hypothesis in a cohort of 192 male endurance athletes with maximal oxygen uptake ≥75 ml ⋅ kg −1 ⋅ min −1 and 189 sedentary male controls. The ACE ID polymorphism in intron 16 was typed with the three-primer polymerase chain reaction method. Both the genotype ( P = 0.214) and allele ( P = 0.095) frequencies were similar in the athletes and the controls. Further analyses in the athletes revealed no excess of the I allele among the athletes within the highest quartile (> 80 ml ⋅ kg −1 ⋅ min −1 ) or decile (>83 ml ⋅ kg −1 ⋅ min −1 ) of maximal oxygen uptake. These data from the GENATHLETE cohort do not support the hypothesis that the ACE ID polymorphism is associated with a higher cardiorespiratory endurance performance level.