Rapid Diagnosis of Azole-Resistant Aspergillosis by Direct PCR Using Tissue Specimens
2010; American Society for Microbiology; Volume: 48; Issue: 4 Linguagem: Inglês
10.1128/jcm.02221-09
ISSN1098-660X
AutoresJan W. M. van der Linden, Eveline Snelders, Jan P. Arends, Simon Daenen, Willem J. G. Melchers, Paul E. Verweij,
Tópico(s)Infectious Diseases and Mycology
ResumoWe report the use of PCR techniques on a formalin-fixed and paraffin-embedded tissue specimen for direct detection of one dominant azole resistance mechanism in a case of disseminated invasive aspergillosis. Rapid detection of mutations associated with azole resistance directly in tissue significantly reduces diagnostic delay.
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