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Transition‐Metal‐Based Lewis Acid and Base Ambiphilic Catalysts of Iridium Hydride Complexes: Multicomponent Synthesis of Glutarimides

2003; Wiley; Volume: 42; Issue: 28 Linguagem: Inglês

10.1002/anie.200351689

1521-3773

Hikaru Takaya, Kazunori Yoshida, Katsuhiro Isozaki, Hiroki Terai, Shun‐Ichi Murahashi,

Synthesis and Catalytic Reactions

Mutual destruction of reagents in acid- and base-promoted reactions in the same container is now avoidable with the iridium polyhydride complex [IrH5(PiPr3)2] (1), which is an ambiphilic Lewis acid and base catalyst. By using catalyst 1, a three-component reaction of nitriles, olefins, and water proceeds efficiently to give glutarimides, which are pharmacologically important (see scheme).