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High Frequency of Mutator Strains among Human Uropathogenic Escherichia coli Isolates

2002; American Society for Microbiology; Volume: 184; Issue: 2 Linguagem: Inglês

10.1128/jb.184.2.605-609.2002

1098-5530

Érick Denamur, Stéphane Bonacorsi, Antoine Giraud, Patrick Duriez, Farida Hilali, Christine Amorin, Édouard Bingen, Antoine Andremont, Bertrand Picard, François Taddéi, Ivan Matić,

DNA Repair Mechanisms

By using a panel of 603 commensal and pathogenic Escherichia coli and Shigella isolates, we showed that mutation rates of strains vary considerably among different ecotypes. Uropathogenic strains had the highest frequency of mutators, while strains from patients with bacteremia had the lowest mutation rates. No correlation between the mutation rates and antibiotic resistance was observed among the studied strains.