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Shedding of herpes simplex virus type 1 into saliva in patients with orofacial fracture

1989; Wiley; Volume: 28; Issue: 2 Linguagem: Inglês

10.1002/jmv.1890280205

1096-9071

Tadamitsu Kameyama, Masato Futami, NOBUHIKO NAKAYOSHI, Chokudo Sujaku, Shigeru Yamamoto,

Head and Neck Surgical Oncology

Abstract Shedding of herpes simplex virus type 1 (HSV‐1) into saliva was studied in 83 patients with orofacial fractures. Infectious virus was isolated from 14 of 83 patients (16.8%) with no detectable herpetic lesion during hospitalization. Of the 83 patients, 44 (53%) had HSV‐1 specific antibody. Virus shedding into saliva was observed only in the patients with antibody to HSV‐1; thus, the frequency of virus shedding patients among those with antibody was 31% (14 of 44 patients). The frequency was obviously higher than that of a healthy population. The period of HSV‐1 shedding had a mean of 3.7 days with range of 1 to 8 days, which is also significantly longer than that of a healthy population. These results strongly suggest that both treatment and operation lead effectively to reactivation of latently infected HSV‐1.