Palladium-catalyzed tandem assembly of norbornene, vinylic halides, and cyanide nucleophile leading to cis-exo-2,3-disubstituted norbornanes
1990; Elsevier BV; Volume: 31; Issue: 37 Linguagem: Inglês
10.1016/s0040-4039(00)98060-2
ISSN1873-3581
AutoresSigeru Torii, Hiroshi Okumoto, Harutoshi Ozaki, Seizo Nakayasu, Takayuki Kotani,
Tópico(s)Organoboron and organosilicon chemistry
ResumoThree components, i.e., norbornene, 1-alkenyl or aryl halide, and cyanide nucleophile, were assembled with palladium catalyst (Pd(OAc)2/PPh3) in DMF at 80 °C to obtain stereoselectively cis-exo-2-cyano-3-alkenyl-or arylnorbornanes, which may be prominent intermediates for the currently attractive PGH analogues.
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