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Small-Cell Carcinoma of the Prostate

2008; Lippincott Williams & Wilkins; Volume: 26; Issue: 7 Linguagem: Inglês

10.1200/jco.2007.14.5409

1527-7755

Christopher J. Anker, Christopher Dechet, Jorge Isaac, Wallace Akerley, Dennis C. Shrieve,

Chromatin Remodeling and Cancer

Small-Cell Carcinoma of the ProstateA 72-year-old man with a 3-year history of obstructive urinary symptoms presented with painless hematuria.On examination, induration was noted along the right lobe of the prostate with a large, firm, irregular mass extending superiorly off the right base of the gland.His prostate-specific antigen (PSA) was 1.6 ng/mL, and a comprehensive metabolic panel and CBC were within normal limits.Transrectal ultrasound-guided biopsy revealed a mixed histology of adenocarcinoma, Gleason grade 4ϩ5, and small-cell carcinoma.A bone scan was normal and abdominopelvic computed tomography (CT) showed a large mass arising from the right base of the prostate and a right internal iliac node suspicious for cancer involvement.He was given a single 3-month injection of leuprolide and referred to the Huntsman Cancer Center at the University of Utah (Salt Lake City, UT), where the pathologic diagnosis was confirmed.Four of six core needle biopsies showed a homogeneous population of blue cells with round nuclei and a salt-and-pepper chromatin pattern consistent with small-cell carcinoma of the prostate (Fig 1A).Gleason 4ϩ5 adenocarcinoma