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Inhibition of the Synthesis of Wax D Peptidoglycolipid of Mycobacterium tuberculosis by d -Cycloserine

1970; American Society for Microbiology; Volume: 1; Issue: 1 Linguagem: Inglês

10.1128/iai.1.1.74-77.1970

1098-5522

Hugo L. David, Dexter S. Goldman, Kuni Takayama,

Biopolymer Synthesis and Applications

The antibiotic d -cycloserine inhibits the synthesis of the wax D peptidoglycolipid in cells of the H37Ra strain of Mycobacterium tuberculosis . This inhibition occurs at a lower concentration of the drug than that required for the inhibition of growth. The inhibition is completely reversed by d -alanine. An arabino-galactan-galactosamine-(diaminopimelic acid)-mycolate accumulates in H37Ra cells exposed to the antibiotic. The chemical and functional group analyses of this lipid suggests it to be a possible precursor to the synthesis of wax D.