Portal de Periódicos da CAPES

Tertiary Aminourea‐Catalyzed Enantioselective Iodolactonization

2010; Wiley; Volume: 49; Issue: 40 Linguagem: Inglês

10.1002/anie.201003681

1521-3773

Gemma E. Veitch, Eric N. Jacobsen,

Catalytic C–H Functionalization Methods

Binding the anion: A highly enantioselective iodolactonization of 5-hexenoic acids has been achieved using a tertiary aminourea-catalyst (see scheme). The use of catalytic iodine in this process is critical to enhancing both the reactivity and enantioselectivity of the stoichiometric I+ source. The mechanism is proposed to involve binding of an iodonium imidate intermediate by the H-bond donor catalyst. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.