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BIBTEX RIS

The case for strategic international alliances to harness nutritional genomics for public and personal health

2005; Cambridge University Press; Volume: 94; Issue: 5 Linguagem: Inglês

10.1079/bjn20051585

1475-2662

Jim Kaput, José M. Ordovás, Lynnette R. Ferguson, Ben van Ommen, Raymond L. Rodriguez, Lindsay H. Allen, Bruce N. Ames, Kenneth A. Dawson, Bruce German, Ronald M. Krauss, Wasyl Malyj, Michael C. Archer, Stephen Barnes, Amelia Bartholomew, Ruth Birk, Peter van Bladeren, Kent J. Bradford, Kenneth H. Brown, Rosane R. Caetano, David Castle, Ruth Chadwick, Stephen E. Clarke, Karine Clément, Craig A. Cooney, Dolores Corella, Ivana Beatrice Mânica da Cruz, Hannelore Daniel, Troy Duster, Sven O. E. Ebbesson, Ruan Elliott, Susan J. Fairweather‐Tait, Jim Felton, Michael Fenech, John W. Finley, Nancy Fogg-Johnson, Rosalynn Gill-Garrison, Michael J. Gibney, Peter J. Gillies, Jan-Ακε Gustafsson, John L. Hartman, Lin He, Jae‐Kwan Hwang, Jean-Philippe Jaı̈s, Yangsoo Jang, Hans‐Georg Joost, Claudine Junien, M.A. Kanter, Warren A. Kibbe, Berthold Koletzko, Bruce R. Korf, Kenneth S. Kornman, David W. Krempin, Dominique Langin, Denis R. Lauren, Jong Ho Lee, Gilbert A. Leveille, Su-Ju Lin, John C. Mathers, Michael Mayne, Warren C. McNabb, John A. Milner, Peter Morgan, Michael Müller, Yuri Nikolsky, Frans van der Ouderaa, Taesun Park, N.A. Pensel, Francisco Pérez‐Jiménez, Kaisa Poutanen, Matthew Roberts, Wim H. M. Saris, Gertrud U. Schuster, Andrew N. Shelling, Artemis P. Simopoulos, Sue Southon, E Shyong Tai, Bradford Towne, Paul Trayhurn, Ricardo Uauy, Willard J. Visek, Craig H. Warden, Rick Weiss, John K. Wiencke, Jack Winkler, George L. Wolff, Xi Zhao-Wilson, Jean‐Daniel Zucker,

Biochemical Analysis and Sensing Techniques

Nutrigenomics is the study of how constituents of the diet interact with genes, and their products, to alter phenotype and, conversely, how genes and their products metabolise these constituents into nutrients, antinutrients, and bioactive compounds. Results from molecular and genetic epidemiological studies indicate that dietary unbalance can alter gene–nutrient interactions in ways that increase the risk of developing chronic disease. The interplay of human genetic variation and environmental factors will make identifying causative genes and nutrients a formidable, but not intractable, challenge. We provide specific recommendations for how to best meet this challenge and discuss the need for new methodologies and the use of comprehensive analyses of nutrient–genotype interactions involving large and diverse populations. The objective of the present paper is to stimulate discourse and collaboration among nutrigenomic researchers and stakeholders, a process that will lead to an increase in global health and wellness by reducing health disparities in developed and developing countries.