Resistance to the Antibiotics Viomycin and Capreomycin in the Streptomyces Species Which Produce Them
1980; Microbiology Society; Volume: 120; Issue: 1 Linguagem: Inglês
10.1099/00221287-120-1-95
ISSN1465-2080
AutoresRichard Skinner, Eric Cundliffe,
Tópico(s)RNA and protein synthesis mechanisms
ResumoViomycin and capreomycin, antibiotics produced by Streptomyces vinaceus and S. capreolus respectively, are potent inhibitors of bacterial protein synthesis. Although these organisms are highly tolerant of their own products in vivo, their ribosomes are fully sensitive to the action of the drugs in vitro. However, they possess novel, antibiotic-inactivating enzymes (viomycin phosphotransferase, capreomycin phosphotransferase, capreomycin acetyl-transferase) which, in addition to possible biosynthetic roles, may contribute to the resistances observed in vivo.
Referência(s)