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Bortezomib: an effective agent in extramedullary disease in multiple myeloma

2006; Wiley; Volume: 76; Issue: 5 Linguagem: Inglês

10.1111/j.0902-4441.2005.t01-1-ejh2462.x

1600-0609

Laura Rosiñol, Ma Teresa Cibeira, Carla Uriburu, Sebastián Yantorno, Olga Salamero, Joan Bladé, Emili Montserrat,

Ubiquitin and proteasome pathways

Abstract: Bortezomib is a potent and selective proteasome inhibitor recently introduced in the treatment of multiple myeloma (MM). This drug produces significant responses in about one‐third of patients with relapsed/refractory disease. We first recognized the lack of efficacy of thalidomide in soft‐tissue plasmacytomas. There is little information on the effect of bortezomib on extramedullary myeloma. Four of 23 patients treated with bortezomib at our institution had extramedullary involvement at the time of relapse. In three of these patients large soft‐tissue plasmacytomas disappeared. This indicates that bortezomib may be useful in clinical situations of extramedullary disease in which other agents, such as thalidomide, may not be effective.