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BIBTEX RIS

Inhibitory Activity of Alkoxyalkyl and Alkyl Esters of Cidofovir and Cyclic Cidofovir against Orthopoxvirus Replication In Vitro

2004; American Society for Microbiology; Volume: 48; Issue: 5 Linguagem: Inglês

10.1128/aac.48.5.1869-1871.2004

ISSN

1098-6596

Autores

Kathy A. Keith, William Wan, Stephanie L. Ciesla, James R. Beadle, Karl Y. Hostetler, Earl R. Kern,

Tópico(s)

Virus-based gene therapy research

Resumo

A new series of ether lipid esters of cidofovir (CDV) were evaluated against vaccinia and cowpox viruses. Activity was dependent on number of atoms in the alkyl or alkoxyalkyl chain, the linker moiety, and the presence of a double bond in the alkoxyalkyl chains linked to the phosphonate moiety of CDV.

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