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Cyclisation/cleavage of macrocycles by ring-closing metathesis on solid support—conformational studies

1997; Royal Society of Chemistry; Issue: 20 Linguagem: Inglês

10.1039/a704976e

1364-548X

Josef Pernerstorfer,

Microbial Natural Products and Biosynthesis

Grubbs' ruthenium metathesis catalyst 1 was used to investigate the catalytic cyclisation/cleavage of tetrapeptide-derived macrocycles from a solid support; the rate dependence on substrate conformation has been studied.