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A Comparison of Two Formulations of Indomethacin (‘Flexin Continus’ Tablets and ‘Indocid’ Capsules) in the Treatment of Rheumatoid Arthritis

1990; Taylor & Francis; Volume: 12; Issue: 2 Linguagem: Inglês

10.1185/03007999009110480

1473-4877

Paul Bacon, R. A. Luqmsni, C. Barry, D. Foley‐Nolan, Rodney Grahame, J. West, B L Hazleman, A. O. Adebsjo, Graham R.V. Hughes, Maheeba Abdullah, E.C. HUSKISSON, Frances McEvoy, A. G. White, Bryan Williams, Paulette Williams, Anthony D. Woolf, A. J. Miller,

Drug-Induced Hepatotoxicity and Protection

SummaryA multi-centre, double-blind, crossover study was carried out in 80 patients with rheumatoid arthritis to compare the efficacy and side-effect profiles of two formulations of indomethacin. Patients were allocated at random to receive 75 mg indomethacin per day either as 1 controlled-release tablet at night or as 1 immediate-release capsule given 3-times a day for a period of 4 weeks before being crossed over to receive the alternative treatment for a further 4 weeks. Pain scores, daily symptomatology and the requirement for escape analgesia recorded by both investigator and patient indicated that controlled-release indomethacin tablets, 75 mg given at night, was as efficacous as immediate-release indomethacin capsules given 3-times daily. However, the controlled-release formulation had a superior side-effect profile with a reduced incidence of abdominal/epigastric pain compared to the immediate-release preparation.Key Words:: Indomethacindelayed action preparationsarthritis. Rheumatoidanalgesicsanti-inflammatory